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To better delineate a forward-looking research agenda, we propose three actionable priorities: (1) establishing quantitative models that correlate the in vivo degradation kinetics of COFs with the magnitude of immune activation they elicit

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Nitrated HGF ( bar 3 , peroxynitrite-treated at 1:2000) lost its activation activity as demonstrated by a drop in the activation index down to the baseline level observed in the negative-control culture ( bar 1 ) 32 and in GSSSG/LASSS-cultures ( bars 6 and 10 , missing HGF)

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The crystals were cryoprotected with 25% glycerol

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